Cisplatin anticancer mechanism

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August undefined, 2024

WebApr 10, 2024 · The current study focuses on the Pd (II) and Pt (II) trinuclear chelates with spermidine (Pd 3 Spd 2 and Pt 3 Spd 2) and aims to evaluate its putative anticancer activity towards cisplatin-resistant TNBC cells (MDA-MB-231/R), as compared to cisplatin-sensitive TNBC (MDA-MB-231), by assessing the (i) antiproliferative activity, (ii) … WebJul 19, 2024 · The mechanisms of anti-cancer drugs brings together learning about transition metals, DNA and ethical considerations in science and medicine. This is an opportunity for cross-curricular debate within …

Platinum drugs and taxanes: can we overcome resistance?

WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … WebA New Molecular Mechanism of Cisplatin Resistance A very recent investigation demonstrated a new mechanism by which the oncoprotein c-Myc enables cancer cells … signs of herniated disc in low back

Cisplatin as an anti-tumor drug: cellular mechanisms of

WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new … Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … Web1152 rows · Jun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. … therapeutic potential 意味

Review on Pharmacology of Cisplatin: Cli…

Cisplatin (Anti-cancer Drug) - SlideShare

WebApr 29, 2024 · In order to overcome cisplatin-resistance, seven cyclometalated ruthenium ( II) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. Web2 days ago · Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli. therapeutic procedure ati template ileostomyWebCisplatin (DDP) has been a significant tumor chemotherapy against various solid malignant tumors, including lung adenocarcinoma, since it was approved by the Food and Drug Association in 1978.7Platinum chemotherapy drugs, represented by DDP, are antitumor agents. therapeutic powder board

"WebJun 20, 2024 · Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of … " - Cisplatin anticancer mechanism

Cisplatin anticancer mechanism

Gene scissors find target for testicular cancer therapy

WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … Web2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid …

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WebJul 1, 2024 · Action mechanism of cisplatin anticancer activity. Cisplatin may also induce cell apoptosis from cell membrane [57]. The type II transmembrane protein and Fas … WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to …

WebApr 13, 2024 · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells stop growing and die. This is because the cytostatic drug causes damage to DNA, the carrier of genetic information, thus stopping the cell cycle. WebA deep knowledge of the biochemical mechanisms, which are triggered in the tumor cell …

WebMar 15, 2011 · Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased DNA repair. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. WebNov 24, 2024 · 1.1. Lung Cancer. Among all forms of cancer, lung cancer is the leading cause of mortality worldwide [1, 2]. Despite advances in development of new treatment modalities, the overall 5-year survival rate has only slightly increased over 2.5 decades, remaining at approximately 16% [4, 5].Early diagnostic procedures and hits, and effective …

WebNov 2, 2024 · Among other cancers, cisplatin is used as a first-line treatment for: leukemia lymphoma breast cancer testicular cancer ovarian cancer head and neck cancer cervical …

WebApr 12, 2024 · The combination of the chemotherapy drugs cisplatin and paclitaxel has long been the standard treatment for women with advanced or recurrent endometrial cancer. But treatment options for these two groups of patients have changed recently, largely because of advances in immunotherapy. therapeutic procedures for hepatitisWebOct 6, 2016 · Multiple mechanisms including tubular epithelial cell toxicity, vasoconstriction in the renal microvasculature and proinflammatory effects contribute to renal dysfunction following exposure to cisplatin. The mechanism of nephrotoxicity is associated with a chloride ion at the cis position of the drug. signs of heroin use eyesWebCisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Although cisplatin, cis-diamminedichloroplatinum(II), has been successfully used in the chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still unclear. therapeutic procedure for diabetes mellitusWebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … signs of heroin withdrawalWebCisplatin (Anti-cancer Drug) 1 of 22 Cisplatin (Anti-cancer Drug) Nov. 19, 2024 • 5 likes • 3,784 views Download Now Download to read offline Education The Slide is about the Anti-cancer Drug (alkylating agent) Cisplatin. AsthaNeupane Follow Advertisement Advertisement Recommended Cisplatin tsclayton 18.8k views • 16 slides Platinum analogs signs of heroin use photosWebJul 1, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine … therapeutic procedures for copd patientsWebSep 18, 2024 · Cisplatin is an antineoplastic agent that came into use in the late 1970s. Cisplatin, while highly toxic, is one of the most heavily utilized chemotherapeutic agents for hematologic and solid tumor malignancies. … therapeutic procedures for diabetes mellitus