Chloroethylnitrosoureas
WebWe investigated the relative contribution of the two Escherichia coli DNA alkyltransferases (ATases) to the increased sensitivity of ATase-deficient bacteria to the mutagenic and lethal effects of chloroethylnitrosoureas (CNU). The ogtencoded protein was the principal determinant in resistance to th … WebThe toxicological profile ofTCNU after acute and 3 months treatment was similar in mice and rats to that of CCNU, with the exception that, TCNU did not cause the chronic liver disturbances found forCCNU. SummaryA novel nitrosourea, 1-(2-chloroethyl)-3-[2-(dimethylaminosulfonyl) ethyl]-1-nitrosourea (TCNU) tauromustine, has been …
Chloroethylnitrosoureas
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WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyl … WebApr 1, 2024 · Chloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC …
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebChloroethylnitrosoureas are anticancer agents that undergo chemical reactions in vitro and in vivo to form active alkylating agents. The rate at which lipophilic chloroethylnitrosourease decompose in serum is faster than in aqueous solution and comparable to in vivo clearance rates.
WebChloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC interstrand crosslinks (ICLs) within DNA double strand. However, the complex process of tumor biology enables tumor cells to escape the killing t … WebChloroethylnitrosoureas (CENUs) are an important family of chemotherapies in clinical treatment of cancers, which exert antitumor activity by inducing the formation of DNA interstrand crosslinks (dG-dC ICLs). However, the drug resistance mediated by O6-alkylguanine-DNA alkyltransferase (A …
WebChloroethylnitrosoureas and temozolomide alkylate DNA at the O6 position of guanine. AGT, which can reverse the alkylation, is inactivated in this process, and its depletion can reverse the drug resistance. Similarly, O6-benzylguanine, a non-cytotoxic substrate of AGT, will deplete the AGT pool.
WebSep 1, 1987 · Abstract. DNA damage caused by methazolastone [an analogue of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide which does not require metabolic activation] was investigated in L-1210 leukemia which is sensitive to this drug and in a L-1210 subline [L-1210/N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU)] which is resistant to both … cctv cameras in homeWebThe U.S. Department of Energy's Office of Scientific and Technical Information cctv cameras in manhattanWebThis paper provides an overview of cancer chemotherapy with special reference to the pharmacokinetics of the nitrosoureas. At physiological PH, the chloroethylnitrosoureas can be decomposed into an isocyanate and 2-chloroethyl diazene hydroxide. Therefore, it is clear that they have both alkylation … cctv cameras in irelandWeb2. Guohui Sun, Lijiao Zhao,* Tengjiao Fan, Sisi Li, Rugang Zhong. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand crosslinks induced by chloroethylnitrosoureas in human glioma cells using a stable isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. … cctv cameras in publicWebMar 1, 1986 · The chloroethylnitrosoureas (CENUs) represent a class of bifunctional alkylating agents that have proved clinically useful for cancer chemotherapy. The group includes carmustine (BCNU), lomustine ... cctv cameras in ruskin flWebApr 15, 2024 · Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation DNA interstrand cross-links (ICLs) are essential for the antitumor activity of chloroethylnitrosoureas (CENUs). cctv cameras in readingWebCompared to 9L cells, 9L-2 cells were very resistant to the cytotoxic effects of 1,3-bis (2-chloroethyl)-1-nitrosourea, and to 2- [3- (2-chloroethyl)-3-nitrosoureido]-D-deoxyglucopyranose. The sensitivity of 9L-7 and 9L-8 cell lines to these drugs was intermediate between 9L and 9L-2. butcher shop bedford