WebJul 13, 2024 · The ChipR’s solution is to marry the traditional putter length of 35 inches with the loft of a current 9-iron (38.5 degrees) to simplify the hitting motion and ultimately the … WebThis motif is known to bind tetratricopeptide repeat (TPR) domain co-chaperones, such as the E3 ubiquitin ligase CHIP. In addition, the EEVD motif also interacts with a structurally distinct...
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RCSB PDB - 4KBQ: Structure of the CHIP-TPR domain …
WebThe nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation. Nucleoporin TPR forms the nuclear basket of the NPC and is crucial for the enrichment of open chromatin around NPCs. TPR has been implicated in the regulation of transcription; … WebApr 23, 2013 · Posttranslational modifications of the Hsc70 lid and tail disrupt key contacts with the CHIP-TPR and may regulate CHIP … WebMar 3, 2015 · CHIP ubiquitinates not just clients bound to Hsp70/Hsc70 but also Hsp70/Hsc70 themselves, targeting lysines in the SBDβ or lid subdomains (Kundrat and Regan, 2010a).Mutations of CHIP-TPR residues that interact with the GPTIEEVD motif are known to abolish the ubiquitination activity of CHIP towards chaperones or chaperone … d3 ncaa womens soccer tournament